Of course, though, House is also a riff on Sherlock Holmes. Consider his impressive deductive powers; where Holmes applies this skill to catching criminals, House applies it to diagnosing diseases. House’s entire process of a differential diagnoses is quite similar to Holmes’ famous method of deduction – once you have ruled out the impossible, whatever remains, however improbably, must be the truth.
There’s plenty of little links and references dotted throughout the series, though; our good doctor in House also lives at 221B, after all – the infamous address of the world’s most famous consulting detective. Further, when House is shot at the end of the second series, the shooter is named in the credits as “Moriarty”; the Napoleon of crime who was involved in the almost death of Sherlock Holmes at the Reichenbach Falls, now immortalised forever as Holmes’ greatest enemy. Even Irene Adler gets a namecheck in the fourth season’s Christmas episode, and in another yuletide special, we see Wilson gift House a “first edition Conan Doyle” book.
My latest post for Yahoo TV, discussing the links between the good detective, and the good Doctor as well.